Outline for BIOL 434: Population Genetics

Michael Whitlock

Week

Topics
1
Review of allele frequencies, Hardy-Weinberg equilibrium, and linkage equilibrium; Hardy-Weinberg equilibrium for multiple alleles and loci
2
Drift : Identity by descent, diffusion, the coalescent
3
Effective population size
4
Mutation: Types of mutations, mutation and drift, neutral theory
5
Selection: Defining and measuring fitness, single locus models
6
Mutation selection balance, frequency dependent selection, gametic selection
7
Selection and drift, selection on two or more loci, estimating selection
8
Inbreeding: Calculation of inbreeding coefficients, mating system evolution
9
Population Subdivision and Migration: Wahlund effect, F statistics, genetic distance
10
Models of population structure, migration and drift, interdemic selection
11
Quantitative Genetics: Heritability, estimating heritability, response to selection
12
Genetic basis of quantitative traits, sources of variance, norms of reaction
13
Maintenance of quantitative variation, response to multivariate selection